Effects of screw configuration on indomethacin dissolution behavior in Eudragit E PO

@inproceedings{Liu2012EffectsOS,
  title={Effects of screw configuration on indomethacin dissolution behavior in Eudragit E PO},
  author={Huiju Liu and Linjie Zhu and Peng Wang and Xueyan Zhang and Costas G. Gogos},
  year={2012}
}
This experimental study examines the evolution of the extent of dissolution of the active pharmaceutical ingredient (API) indomethacin (INM) into the polymer excipient Eudragit E PO (E PO) on four screw configurations processed in an APV 15 mm corotating twin screw extruder. The screws were pulled out and quenched by water, which allowed for quick access to the processed stream carcass. Polarized light microscopy (PLM), scanning electron microscopy (SEM), and Fourier transform infrared… CONTINUE READING

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