Effects of saw palmetto extract on micturition reflex of rats and its autonomic receptor binding activity.

  title={Effects of saw palmetto extract on micturition reflex of rats and its autonomic receptor binding activity.},
  author={Tomomi Oki and Mayumi Suzuki and Yasuhiko Nishioka and Akio Yasuda and Keizo Umegaki and Shizuo Yamada},
  journal={The Journal of urology},
  volume={173 4},
PURPOSE We examined the effects of saw palmetto extract (SPE) on the rat micturition reflex and on autonomic receptors in the lower urinary tract. MATERIALS AND METHODS The effect of SPE was examined on cystometrograms of anesthetized rats induced by intravesical infusion of saline or 0.1% acetic acid. SHR/NDmc-cp (cp/cp) rats received repeat oral administration of SPE and nighttime urodynamic function was determined. The autonomic receptor binding activity of SPE in the rat bladder and… 
Pharmacological effects of saw palmetto extract in the lower urinary tract
Oral administration of SPE has been shown to attenuate the up-regulation of alpha(1)-adrenoceptors in the rat prostate induced by testosterone, thereby improving urinary dysfunction in patients with BPH and an overactive bladder.
Beneficial Effects of Saw Palmetto Fruit Extract on Urinary Symptoms in Japanese Female Subjects by a Multicenter, Randomized, Double-Blind, Placebo-Controlled Study
The present study is the first to demonstrate the potential of SPE to mitigate LUTS in adult women and reveals that SPE alleviated the symptoms of daytime frequency and nocturia in a subset of subjects with a CLSS Q5 score of 1 or higher.
The Therapeutic Potential of Saw Palmetto Extract in Urological Disorders
The pharmacological properties of Saw palmetto extract are summarized, the possible therapeutic mechanisms of SPE in urological diseases are discussed, and a potential therapeutic approach in the clinical treatment of patients with BPH, prostate cancer, chronic prostatitis (CP) and erectile dysfunction (ED) is highlighted.
Effects of Saw Palmetto Extract on Urodynamic Parameters, Bladder Muscarinic and Purinergic Receptors and Urinary Cytokines in Rats with Cyclophosphamide‐Induced Cystitis
To clarify the effect of saw palmetto extract (SPE), a phytotherapeutic agent, on urodynamic parameters, bladder muscarinic and purinergic receptors, and urinary cytokines in rats with cystitis
A phytosterol-enriched saw palmetto supercritical CO2 extract ameliorates testosterone-induced benign prostatic hyperplasia by regulating the inflammatory and apoptotic proteins in a rat model
Histological examination of prostate tissue samples showed that VISPO treatment was comparatively better than SPO in improving the hyperplastic patterns, and experimental evidence that β-sitosterol enriched saw palmetto oil could be higher efficacious in treating the BPH complications compared to the conventional saw paletto oil preparations is provided.
Pharmacologically relevant receptor binding characteristics and 5alpha-reductase inhibitory activity of free Fatty acids contained in saw palmetto extract.
It is suggested that lauric acid and oleic acid bind noncompetitively to alpha(1)-adrenergic, muscarinic and 1,4-DHP calcium channel antagonist receptors, as well as a novel and convenient method of determining 5alpha-reductase activity using LC/MS.
Effects of saw palmetto fruit extract intake on improving urination issues in Japanese men: A randomized, double‐blind, parallel‐group, placebo‐controlled study
The consumption of saw palmetto fruit extract capsule for 12 weeks relieved subjective symptoms related to urination, which suggests improvement of the issue in healthy Japanese men.
What do we know about phytotherapy of benign prostatic hyperplasia?
A double blind, placebo-controlled randomized comparative study on the efficacy of phytosterol-enriched and conventional saw palmetto oil in mitigating benign prostate hyperplasia and androgen deficiency
The efficacy of β-sitosterol enriched saw palmetto oil superior to conventional oil is demonstrated thus extending the scope of effective BPH and androgen deficiency treatment with improved quality of life through the intake of functional ingredients.


The anticholinergic activity of agents indicated for urinary incontinence is an important property for effective control of bladder dysfunction.
It is suggested that the anticholinergic component of the drugs' action is important in current effective therapies of bladder dysfunction, and the possibility that other ancillary activities may also contribute to the specific mechanism of action of these agents in the urinary bladder is not ruled out.
Spinal and peripheral mechanisms contributing to hyperactive voiding in spontaneously hypertensive rats.
Alterations in bladder function of SHR appear to be associated with changes in the noradrenergic control of the micturition reflex, in addition to an increased smooth muscle and decreased neuronal responsiveness to norepinephrine.
Increased c-fos expression in spinal neurons after irritation of the lower urinary tract in the rat
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Results suggest that neurons in several regions of the spinal cord are involved in processing afferent input from different parts of the LUT, and Neurons in the DCM appear to have an important role since they respond to both nociceptive and non- nocICEptive inputs and to visceral and somatic nerve afferent pathways.
Effect of Serenoa repens extract (Permixon) on estradiol/testosterone-induced experimental prostate enlargement in the rat.
It is demonstrated that administering LSESR to hormone-treated castrated rats inhibits the increase in prostate wet weight, which may explain the beneficial effect of this extract in human benign prostatic hypertrophy.
[Comparison of a phytotherapeutic agent (Permixon) with an alpha-blocker (Tamsulosin) in the treatment of benign prostatic hyperplasia: a 1-year randomized international study].
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Supraspinal N‐methyl‐D‐aspartate receptor inhibition influences the micturition reflex and function of the upper urinary tract of anesthetized and conscious rats
To examine the effects of N‐methyl‐D‐aspartate (NMDA) receptor antagonists on the frequency/volume (F/V) characteristics of micturition of conscious and anesthetized rats in relation to the
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In men with benign prostatic hyperplasia, terazosin was effective therapy, whereas finasteride was not, and the combination of terazOSin and finasterside was no more effective than terazoshin alone.