Effects of salicylate on transient outward and delayed rectifier potassium channels in rat inferior colliculus neurons

@article{Liu2004EffectsOS,
  title={Effects of salicylate on transient outward and delayed rectifier potassium channels in rat inferior colliculus neurons},
  author={Yanxing Liu and Xuepei Li},
  journal={Neuroscience Letters},
  year={2004},
  volume={369},
  pages={115-120}
}
The effects of salicylate (a tinnitus inducer) were studied on the transient outward potassium current (I(K(A))) and the delayed rectifier potassium current (I(K(DR))) in acutely dissociated rat inferior colliculus neurons by the whole-cell voltage-clamp method. Salicylate's inhibition of the amplitude of I(K(A)) and I(K(DR)) was concentration-dependent. The IC(50) values for the blocking action of salicylate on I(K(A)) and I(K(DR)) were 2.27 and 0.80 mM, respectively. At a concentration of 1… CONTINUE READING