Effects of salicylate on the incorporation of orotic acid into nucleic acids of mouse tissues in vivo

@article{Janakidevi1970EffectsOS,
  title={Effects of salicylate on the incorporation of orotic acid into nucleic acids of mouse tissues in vivo},
  author={K. Janakidevi and M. Smith},
  journal={Journal of Pharmacy and Pharmacology},
  year={1970},
  volume={22}
}
In mice, given intraperitoneal injections of orotic acid‐5‐3H, two peaks of incorporation of radioactivity at 30 min and 6 h occurred in the RNA of kidney and of liver and its subcellular components. The concurrent administration of salicylate, in doses of 200 mg/kg body weight and above, significantly inhibited the incorporation of the labelled orotic acid at 30 min but not at 6 h. 
14 Citations
Inhibition by aspirin of ribose conjugation in the metabolism of histamine.
Salicylate and enzymes
Effects of aspirin and acetaminophen on fetal and placental growth in rats.
The selective inhibition of microbial RNA synthesis by salicylate.
...
1
2
...

References

SHOWING 1-10 OF 14 REFERENCES
The distribution of salicylate in mouse tissues after intraperitoneal injection
Ribonucleic acid synthesis during the early action of thyroid hormones.
Studies on the nature of polysomes.
Action of sodium salicylate and related compounds on tissue metabolism in vitro.
  • T. Brody
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1956
"J."
Inhibition of nucleic acid polymerases by salicylate in vitro
Biochem
  • J., 98, 604-620.
  • 1966
The effects of salicylates on growth in immature rats.
...
1
2
...