Effects of salicylate on RNA polymerase activity and on the incorporation of orotic acid and thymidine into the nucleic acids of rat foetuses in vitro

@article{Janakidevi1970EffectsOS,
  title={Effects of salicylate on RNA polymerase activity and on the incorporation of orotic acid and thymidine into the nucleic acids of rat foetuses in vitro},
  author={K. Janakidevi and M. Smith},
  journal={Journal of Pharmacy and Pharmacology},
  year={1970},
  volume={22}
}
Salicylate (10 mM) significantly inhibited the activity of RNA polymerase and the incorporation of radioactivity from orotic acid‐5‐3H and thymidine‐6‐3H into whole 13 day and 16 day rat foetuses. The polymerase activity and the incorporation of the labelled orotate were significantly inhibited by 2 mM salicylate in the 16 day foetus only. The inhibitory action of salicylate on RNA biosynthesis may be related to its effects in causing an increased incidence of foetal death and congenital… Expand
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References

SHOWING 1-10 OF 13 REFERENCES
Action of sodium salicylate and related compounds on tissue metabolism in vitro.
  • T. Brody
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1956
Premature Birth induced in Mice by Salicylate
The distribution of salicylate in mouse tissues after intraperitoneal injection
Congenital malformations and environmental influences in pregnancy.
  • I. Richards
  • Medicine
  • British journal of preventive & social medicine
  • 1969
Inhibition of nucleic acid polymerases by salicylate in vitro
A procedure for the isolation of enzymically active rat-liver nuclei.
...
1
2
...