Effects of rutin on oxidative stress in mice with kainic acid-induced seizure.

  title={Effects of rutin on oxidative stress in mice with kainic acid-induced seizure.},
  author={Marjan Nassiri-Asl and Taghi Naserpour Farivar and Esmail Abbasi and Hamid Reza Sadeghnia and Mehdi Sheikhi and Mina Lotfizadeh and Parisa Bazahang},
  journal={Journal of integrative medicine},
  volume={11 5},
OBJECTIVE Flavonoids are present in foods such as fruits and vegetables. Several studies have demonstrated a relationship between the consumption of flavonoid-rich foods and prevention of human disease, including neurodegenerative disorders. We assessed the effect of rutin (quercetin-3-O-rutinoside) on oxidative stress in kainic acid (KA)-induced seizure. METHODS Thirty-six BALB/c mice were randomly divided into three groups. In the control group, saline (intra-peritoneal, i.p.) was… 

Figures from this paper

Dose-Dependent Behavioral and Antioxidant Effects of Quercetin and Methanolic and Acetonic Extracts from Heterotheca inuloides on Several Rat Tissues following Kainic Acid-Induced Status Epilepticus

Protection against damage in brain regions of male Wistar rats treated with KA suggests that organic extracts and quercetin from H. inuloides exert anticonvulsant effects via direct scavenging of reactive oxygen species (ROS) and modulation of antioxidant enzyme activity.

Effect of quercetin and rutin in some acute seizure models in mice

Effect of thiamazole on kainic acid-induced seizures in mice

Protective Effects of Aqueous Extract of Luehea divaricata against Behavioral and Oxidative Changes Induced by 3-Nitropropionic Acid in Rats

The results suggest that rats pretreated with L. divaricata prior to 3-NP treatment showed neuroprotective effects when compared to3-NP treated controls, which may be due to its antioxidant properties.

Neuroprotective effect of Alpinia galanga against neurodegeneration in the rat hippocampus induced by kainic acid

Alpinia galanga extract showed the neuroprotective effect in KA-induced neurodegeneration, as evident by the significant increase of neuron density but decrease the percent of GFAP immunoreactive expression compared with the vehicle-treated group with KA injection.

The effects of different fractions of Coriandrum sativum on pentylenetetrazole-induced seizures and brain tissues oxidative damage in rats

It is shown that different fractions of C. sativum possess antioxidant activity in the brain and WF and EAF of this plant have anticonvulsant effects.

Role of Rutin in 5-Fluorouracil-Induced Intestinal Mucositis: Prevention of Histological Damage and Reduction of Inflammation and Oxidative Stress

Results suggest that the COX-2 pathway is one of the underlying protective mechanisms of RUT against 5-FU-induced intestinal mucositis.

Electrophysiological and Neurochemical Assessment of Selenium Alone or Combined with Carbamazepine in an Animal Model of Epilepsy

The electrophysiological and neurochemical data proved the potential of these techniques in evaluating the treatment’s efficiency and suggest that supplementation of Se with antiepileptic drugs (AEDs) may be beneficial in ameliorating most of the alterations induced in the brain as a result of seizure insults and could be recommended as an adjunct therapy with AEDs.



Naringin protects against kainic acid-induced status epilepticus in rats: evidence for an antioxidant, anti-inflammatory and neuroprotective intervention.

The results of this study suggest that naringin has therapeutic potential since it suppresses KA-induced seizures, cognitive impairment and oxidative stress in the brain and is a result of its antioxidant and anti-inflammatory activity.


The results suggest that melatonin may be protective against central nervous system pathologies involving excitotoxicity or where oxidative damage may contribute to mitochondrial dysfunction.

The effect of flavonoids on rat heart mitochondrial function.