Effects of rutin on acrylamide-induced neurotoxicity

Abstract

Rutin is an important flavonoid that is consumed in the daily diet. The cytoprotective effects of rutin, including antioxidative, and neuroprotective have been shown in several studies. Neurotoxic effects of acrylamide (ACR) have been established in humans and animals. In this study, the protective effects of rutin in prevention and treatment of neural toxicity of ACR were studied. Rutin significantly reduced cell death induced by ACR (5.46 mM) in time- and dose-dependent manners. Rutin treatment decreased the ACR-induced cytotoxicity significantly in comparison to control (P <0.01, P < 0.001). Rutin (100 and 200 mg/kg) could prevent decrease of body weight in rats. In combination treatments with rutin (50, 100 and 200 mg/kg), vitamin E (200 mg/kg) and ACR, gait abnormalities significantly decreased in a dose-dependent manner (P < 0.01 and P < 0.001). The level of malondialdehyde significantly decreased in the brain tissue of rats in both preventive and therapeutic groups that received rutin (100 and 200 mg/kg). It seems that rutin could be effective in reducing neurotoxicity and the neuroprotective effect of it might be mediated via antioxidant activity.

DOI: 10.1186/2008-2231-22-27

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@inproceedings{Motamedshariaty2013EffectsOR, title={Effects of rutin on acrylamide-induced neurotoxicity}, author={Vahideh Sadat Motamedshariaty and Sara Amel Farzad and Marjan Nassiri-Asl and Hossein Hosseinzadeh}, booktitle={DARU Journal of Pharmaceutical Sciences}, year={2013} }