Effects of rosuvastatin on serum asymmetric dimethylarginine levels and atrial structural remodeling in atrial fibrillation dogs.

@article{Li2012EffectsOR,
  title={Effects of rosuvastatin on serum asymmetric dimethylarginine levels and atrial structural remodeling in atrial fibrillation dogs.},
  author={Jingjie Li and Wei Xia and Wei Feng and Xiufen Qu},
  journal={Pacing and clinical electrophysiology : PACE},
  year={2012},
  volume={35 4},
  pages={456-64}
}
BACKGROUND Circulating asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, is increased in atrial fibrillation (AF). The purpose of this study was to investigate the effects of rosuvastatin on serum ADMA levels and atrial structural remodeling in AF dogs induced by chronic rapid atrial pacing. METHODS Twenty dogs were randomly divided into the sham-operated (n=6), control (n=7), or rosuvastatin (n=7) groups. Sustained AF was induced by rapid pacing of the right… CONTINUE READING