Effects of rosuvastatin on 3-nitrotyrosine and aortic stiffness in hypercholesterolemia.

@article{Pirro2007EffectsOR,
  title={Effects of rosuvastatin on 3-nitrotyrosine and aortic stiffness in hypercholesterolemia.},
  author={Matteo Pirro and Giuseppe Schillaci and Massimo Raffaele Mannarino and Gianluca Savarese and Gaetano Vaudo and Donatella Siepi and Rita Paltriccia and Elmo Mannarino},
  journal={Nutrition, metabolism, and cardiovascular diseases : NMCD},
  year={2007},
  volume={17 6},
  pages={436-41}
}
BACKGROUND AND AIMS Early atherosclerosis is characterized by reduced large artery distensibility, paralleled by an increased peroxynitrite formation and nitration of tyrosine in proteins. The aim of the present study was to investigate the short-term effect of cholesterol lowering with rosuvastatin on 3-nitrotyrosine (3-NT), a marker of peroxynitrite-mediated oxidative stress, and on arterial stiffness. METHODS AND RESULTS 71 outpatients with primary hypercholesterolemia were recruited for… CONTINUE READING
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