Effects of rosiglitazone on the liver histology and mitochondrial function in ob/ob mice.

@article{GarcaRuiz2007EffectsOR,
  title={Effects of rosiglitazone on the liver histology and mitochondrial function in ob/ob mice.},
  author={Inmaculada Garc{\'i}a-Ruiz and Cristina Rodr{\'i}guez-Juan and Teresa D{\'i}az-Sanju{\'a}n and Miguel {\'A}ngel Mart{\'i}nez and Teresa Muņoz-Yag{\"u}e and Jos{\'e} Antonio Sol{\'i}s-Herruzo},
  journal={Hepatology},
  year={2007},
  volume={46 2},
  pages={414-23}
}
UNLABELLED Insulin resistance is present in almost all patients with nonalcoholic steatohepatitis (NAFLD), and mitochondrial dysfunction likely plays a critical role in the progression of fatty liver into nonalcoholic steatohepatitis. Rosiglitazone, a selective ligand of peroxisome proliferator-activated receptor gamma (PPARgamma), is an insulin sensitizer drug that has been used in a number of insulin-resistant conditions, including NAFLD. The aim of this study was to analyze the effects of… CONTINUE READING

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