Effects of ropivacaine on human neutrophil function: comparison with bupivacaine and lidocaine.

@article{Mikawa2003EffectsOR,
  title={Effects of ropivacaine on human neutrophil function: comparison with bupivacaine and lidocaine.},
  author={Katsuya Mikawa and H Akamarsu and Kahoru Nishina and Makoto Shiga and Hidefumi Obara and Yukie Niwa},
  journal={European journal of anaesthesiology},
  year={2003},
  volume={20 2},
  pages={104-10}
}
BACKGROUND AND OBJECTIVE Neutrophils are important both for the immunological defence system and for the inflammatory tissue autoinjury mechanism. However, many local anaesthetics impair certain neutrophil functions. The aim was to assess the effects of ropivacaine, bupivacaine and lidocaine on human neutrophils from adult volunteers. METHODS Chemotaxis, phagocytosis, reactive oxygen species production, intracellular calcium ion ([Ca2+]i) concentrations and protein kinase C activity were… CONTINUE READING