Effects of ropivacaine on a potassium channel (hKv1.5) cloned from human ventricle.


BACKGROUND Ropivacaine, a new amide local anesthetic agent chemically related to bupivacaine, is able to induce early after depolarizations in isolated cardiac preparations. The underlying mechanism by which ropivacaine induces this effect has not been explored, but it is likely to involve K+ channel block. METHODS Cloned human cardiac K+ channels (hKv1.5… (More)


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