Effects of risperidone, clozapine and the 5-HT6 antagonist GSK-742457 on PCP-induced deficits in reversal learning in the two-lever operant task in male Sprague Dawley rats

@article{Bruin2013EffectsOR,
  title={Effects of risperidone, clozapine and the 5-HT6 antagonist GSK-742457 on PCP-induced deficits in reversal learning in the two-lever operant task in male Sprague Dawley rats},
  author={N.M.W.J. de Bruin and Marlies Van Drimmelen and Marjolein S. Kops and Jan Folkert Van Elk and M. Middelveld-van de Wetering and Isabel Schwienbacher},
  journal={Behavioural Brain Research},
  year={2013},
  volume={244},
  pages={15-28}
}

Figures and Tables from this paper

The subchronic phencyclidine rat model: relevance for the assessment of novel therapeutics for cognitive impairment associated with schizophrenia
TLDR
The multi-site study confirmed that scPCP impaired NOR and ASST only and demonstrated the reproducibility and usefulness of the touchscreen approach and recommended further work is required to understand the neurochemical changes and specificity of the cognitive deficits.
Pharmacological evidence that 5-HT2C receptor blockade selectively improves decision making when rewards are paired with audiovisual cues in a rat gambling task
TLDR
These findings demonstrate that the 5-HT2 receptor-mediated regulation of risky decision making and motor impulsivity can be pharmacologically dissociated and further show that the presence of highly salient reward-paired cues critically alters the neurochemical regulation of the choice process.
Examining the effects of a sub-chronic exposure to phencyclidine: An analysis of functional network connectivity, behavior, and mRNA expression
TLDR
The manipulation and examination of glutamate has been and continues to be pivotal in experimental research and a growing interest in observing functional network connectivity (FNC) has lead to research into its role in disease states.
The procognitive effects of 5-HT6 receptor ligands in animal models of schizophrenia
  • A. Nikiforuk
  • Psychology, Biology
    Reviews in the neurosciences
  • 2014
TLDR
This review focuses primarily on animal models of schizophrenia that are based on the blockade of N-methyl-d-aspartate receptors; however, when relevant, data obtained in other models are also discussed.
Comparative effect of lurasidone and blonanserin on cortical glutamate, dopamine, and acetylcholine efflux: role of relative serotonin (5‐HT)2A and DA D2 antagonism and 5‐HT1A partial agonism
TLDR
The ability to increase cortical DA efflux was the only shared effect of the compounds which ameliorates the deficit in cognition in rodents following phencyclidine.
...
...

References

SHOWING 1-10 OF 94 REFERENCES
The atypical antipsychotic ziprasidone, but not haloperidol, improves phencyclidine-induced cognitive deficits in a reversal learning task in the rat
TLDR
PCP produced a selective reversal learning deficit in rats, which was ameliorated following treatment with ziprasidone but not haloperidol, which reversed the impairment caused by PCP.
Reversal of Subchronic PCP-Induced Deficits in Attentional Set Shifting in Rats by Sertindole and a 5-HT6 Receptor Antagonist: Comparison Among Antipsychotics
TLDR
The data suggest that the combination of 5-HT6 antagonistic activity and the absence of antimuscarinic activity may represent key characteristics of the pharmacological profile for improved antipsychotic drugs for schizophrenia.
Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT6 and 5-HT2A receptor mechanisms
TLDR
The efficacies of selective 5-HT2A and5-HT6 receptor antagonists suggest potential mechanisms mediating the effects of sertindole, which has high affinity for these 5- HT receptor subtypes.
Investigation of the effects of lamotrigine and clozapine in improving reversal-learning impairments induced by acute phencyclidine and d-amphetamine in the rat
TLDR
The model is validated further using the atypical antipsychotic clozapine and the effects of lamotrigine, a broad-spectrum anticonvulsant that is known to reduce glutamate release in vitro and is able to prevent ketamine-induced psychotic symptoms in healthy human volunteers are investigated.
Comparison of haloperidol, risperidone, sertindole, and modafinil to reverse an attentional set-shifting impairment following subchronic PCP administration in the rat—a back translational study
TLDR
Findings further support that the rat ID–ED test in subchronic PCP-treated rats has utility and validity as a preclinical model of the cognitive symptoms of schizophrenia and demonstrates back-translational potential.
The NMDA-receptor antagonist MK-801 selectively disrupts reversal learning in rats
TLDR
It is concluded that NMDA receptor blockade leads to a selective impairment in cognitive flexibility, and shows some similarity to transient inactivation of the medial prefrontal cortex in this respect.
Sub-chronic psychotomimetic phencyclidine induces deficits in reversal learning and alterations in parvalbumin-immunoreactive expression in the rat
TLDR
Findings parallel findings of profound hippocampal and more subtle cortical deficits of parvalbumin-IR neurons in schizophrenia, and provide evidence to suggest that sub-chronic PCP can induce a lasting cognitive deficit, an effect that may be related to the observed neuronal deficits.
A within-subject cognitive battery in the rat: differential effects of NMDA receptor antagonists
TLDR
NMDA receptor-dependent mechanisms are requisite in the acquisition of a simple conditional discrimination and consolidation of extinction in rats and appear to be less critical and potentially specific to the paradigm and NMDA receptor antagonist used.
...
...