Effects of reversible inactivation of the neonatal ventral hippocampus on behavior in the adult rat.

@article{Lipska2002EffectsOR,
  title={Effects of reversible inactivation of the neonatal ventral hippocampus on behavior in the adult rat.},
  author={Barbara K. Lipska and Nader D Halim and Pavan N. Segal and Daniel R. Weinberger},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 7},
  pages={2835-42}
}
Rats with neonatal excitotoxic damage of the ventral hippocampus display in adulthood a variety of abnormalities reminiscent of schizophrenia and are used as an animal model of this disorder. In the present study, we hypothesized that transient inactivation of ventral hippocampal activity during a critical developmental period may be sufficient to disrupt normal maturation of relevant brain systems and produce similar lasting behavioral changes. We infused tetrodotoxin (TTX) or artificial CSF… CONTINUE READING

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References

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Blockade of neuronal activity during hippocampal development produces a chronic focal epilepsy in the rat.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2000
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