Effects of reversible inactivation of locus coeruleus on long-term potentiation in perforant path-DG synapses in rats.

The locus coeruleus (LC) is the main source of noradrenergic innervations to the forebrain and the hippocampal formation but does not receive noradrenergic projections itself. Previous studies have suggested that hippocampal neural response is modulated by the noradrenergic pathway and that the experimental activation of the LC can potentiate hippocampal… CONTINUE READING