Effects of retinoids on tooth morphogenesis and cytodifferentiations, in vitro.

  title={Effects of retinoids on tooth morphogenesis and cytodifferentiations, in vitro.},
  author={Manuel P. Mark and Agn{\`e}s Bloch-Zupan and Jean Victor Ruch},
  journal={The International journal of developmental biology},
  volume={36 4},
The first embryonic lower mouse molar was used as a model system to investigate the effects of two retinoids, retinoic acid (RA) and a synthetic analogue, Ch55, on morphogenesis and cytodifferentiations in vitro. Exogenous retinoids were indispensable for morphogenesis of bud, cap and bell-stage molars in serum-free, chemically-defined, culture media. Transferrin and RA or transferrin and Ch55 acted synergistically in promoting morphogenesis from bud and cap-stage explants. Transferrin, per se… CONTINUE READING
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