Effects of retinoids on the TGF-beta system and extracellular matrix in experimental glomerulonephritis.

@article{Morath2001EffectsOR,
  title={Effects of retinoids on the TGF-beta system and extracellular matrix in experimental glomerulonephritis.},
  author={Christian Morath and C. D. Dechow and Ingo Lehrke and Volker Haxsen and Ruediger Waldherr and J{\"u}urgen Floege and Eberhardt Ritz and J{\"u}rgen Dipl.-Ing. Wagner},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2001},
  volume={12 11},
  pages={
          2300-9
        }
}
Transforming growth factor-beta1 (TGF-beta 1) overexpression plays a key role in the glomerular accumulation of extracellular matrix proteins in renal disease. Retinoids have previously been shown to significantly limit glomerular damage in rat experimental glomerulonephritis. Therefore, the effects of all-trans retinoic acid and isotretinoin on the components of the TGF-beta system and extracellular matrix proteins in anti-Thy1.1-nephritis (Thy-GN) were investigated. Vehicle-injected control… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 21 CITATIONS

Vitamin A deficiency results in dysregulation of lipid efflux pathway in rat kidney

  • Pediatric Nephrology
  • 2010
VIEW 14 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Chronic low-dose isotretinoin treatment limits renal damage in subtotally nephrectomized rats

  • Journal of Molecular Medicine
  • 2008
VIEW 5 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

TGF-β signaling in the kidney: profibrotic and protective effects.

  • American journal of physiology. Renal physiology
  • 2016
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 49 REFERENCES

Retinoic acid reduces glomerular injury in a rat model of glomerular damage.

  • Journal of the American Society of Nephrology : JASN
  • 2000
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL