Corpus ID: 5455208

Effects of retinoids on the TGF-beta system and extracellular matrix in experimental glomerulonephritis.

  title={Effects of retinoids on the TGF-beta system and extracellular matrix in experimental glomerulonephritis.},
  author={C. Morath and C. Dechow and I. Lehrke and V. Haxsen and R. Waldherr and J. Floege and E. Ritz and J. Wagner},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={12 11},
  • C. Morath, C. Dechow, +5 authors J. Wagner
  • Published 2001
  • Medicine
  • Journal of the American Society of Nephrology : JASN
  • Transforming growth factor-beta1 (TGF-beta 1) overexpression plays a key role in the glomerular accumulation of extracellular matrix proteins in renal disease. Retinoids have previously been shown to significantly limit glomerular damage in rat experimental glomerulonephritis. Therefore, the effects of all-trans retinoic acid and isotretinoin on the components of the TGF-beta system and extracellular matrix proteins in anti-Thy1.1-nephritis (Thy-GN) were investigated. Vehicle-injected control… CONTINUE READING
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