Effects of retinoids on metabolizing enzymes and on binding of benzo(a)pyrene to rat tissue DNA.

  title={Effects of retinoids on metabolizing enzymes and on binding of benzo(a)pyrene to rat tissue DNA.},
  author={D J Mccarthy and Charles Lindamood and Donald L. Hill},
  journal={Cancer research},
  volume={47 19},
Retinyl acetate, 13-cis-retinoic acid (13cisRA), and N-(4-hydroxyphenyl)-retinamide (4HPR) were assayed for their in vivo effects on hepatic levels of cytochrome P450, cytosolic glutathione-S-transferase, and quinone reductase. When given p.o. to Sprague-Dawley rats, all of the retinoids caused significant suppression in the levels of arylhydrocarbon hydroxylase, yet 13cisRA and 4HPR caused elevations in cytosolic levels of quinone reductase and glutathione-S-transferase, respectively. Scans of… CONTINUE READING
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