Effects of retinoids on glycosaminoglycan synthesis by human skin fibroblasts grown as monolayers and within contracted collagen lattices.

@article{Edward1995EffectsOR,
  title={Effects of retinoids on glycosaminoglycan synthesis by human skin fibroblasts grown as monolayers and within contracted collagen lattices.},
  author={Michael Kehinde Edward},
  journal={The British journal of dermatology},
  year={1995},
  volume={133 2},
  pages={
          223-30
        }
}
  • Michael Kehinde Edward
  • Published 1995
  • Medicine
  • The British journal of dermatology
  • Fibroblasts grown within contracted collagen lattices synthesize substantially less glycosaminoglycans than fibroblasts grown as monolayers on a plastic substrate. [3H]glucosamine incorporation into hyaluronate was reduced by 70%, and incorporation into sulphated glycosaminoglycans was reduced by 40%. However, incorporation into heparan sulphate and chondroitin sulphates was reduced by 14 and 49%, respectively, resulting in a substantial change in the proportions of the individual… CONTINUE READING

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