Effects of retinoids and role of retinoic acid receptors in human thyroid carcinomas and cell lines derived therefrom.

@article{Schmutzler1996EffectsOR,
  title={Effects of retinoids and role of retinoic acid receptors in human thyroid carcinomas and cell lines derived therefrom.},
  author={Cornelia Schmutzler and J{\'u}lius Brtko and K Bienert and Josef Koehrle},
  journal={Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association},
  year={1996},
  volume={104 Suppl 4},
  pages={16-9}
}
Retinoic acids (RAs), well characterized regulators of proliferation and differentiation, partly re-differentiate follicular thyroid carcinoma cell lines (FTC-133, FTC-238, and HTC-TSHr) as well as SV40-transfected immortalized thyroid cell lines (ori3 and 7751). This is indicated by the stimulation of type I 5'-deiodinase and other differentiation markers. As demonstrated by RT-PCR, electrophoretic mobility shift, and [3H]-retinoic acid binding assays, thyroid carcinoma cell lines express RA… CONTINUE READING

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