Effects of response requirement upon human sedative self-administration and drug-seeking behavior.

Abstract

Five male volunteers with histories of sedative drug abuse were given the opportunity to self-administer up to 20 oral doses per day of either diazepam (10 mg per dose) or sodium pentobarbital (30 mg per dose). Each dose was purchased with tokens earned by exercising on a stationary exercise bicycle. Each two minutes of exercise earned one token. In a mixed… (More)

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