Effects of reserpine on nerve stimulation-induced constrictions in canine isolated splenic artery.

@article{Yang2003EffectsOR,
  title={Effects of reserpine on nerve stimulation-induced constrictions in canine isolated splenic artery.},
  author={Xiao-Ping Yang and Shigetoshi Chiba},
  journal={Clinical and experimental pharmacology & physiology},
  year={2003},
  volume={30 7},
  pages={
          452-6
        }
}
1. Our previous studies have demonstrated that peri-arterial electrical nerve stimulation (PNS) of the canine splenic artery induces a double-peaked vasoconstriction consisting of an initial transient, dominantly P2X purinoceptor-mediated constriction, followed by a prolonged, mainly alpha1-adrenoceptor-induced response. In the present study, we examined the effects of reserpine on PNS-induced double-peaked responses. 2. The vasoconstrictor response to tyramine was abolished after reserpine… CONTINUE READING