Effects of representative glucocorticoids on TNFα- and CD40L-induced NF-κB activation in sensor cells.

@article{Cechin2014EffectsOR,
  title={Effects of representative glucocorticoids on TNFα- and CD40L-induced NF-κB activation in sensor cells.},
  author={Sirlene R. Cechin and Peter Buchwald},
  journal={Steroids},
  year={2014},
  volume={85},
  pages={36-43}
}
Glucocorticoids are an important class of anti-inflammatory/immunosuppressive drugs. A crucial part of their anti-inflammatory action results from their ability to repress proinflammatory transcription factors such as nuclear factor-κB (NF-κB) and activator protein-1 (AP-1) upon binding to the glucocorticoid receptor (GR). Accordingly, sensor cells quantifying their effect on inflammatory signal-induced NF-κB activation can provide useful information regarding their potencies as well as their… CONTINUE READING