Effects of repetitive administration of growth hormone-releasing hormone on growth hormone secretion, insulin-like growth factor I, and bone metabolism in postmenopausal women.

@article{Franchimont1989EffectsOR,
  title={Effects of repetitive administration of growth hormone-releasing hormone on growth hormone secretion, insulin-like growth factor I, and bone metabolism in postmenopausal women.},
  author={Paul Franchimont and D Urbain-Choffray and P Lambelin and Micka{\"e}l Fontaine and Gerald Frangin and Jean-Yves Reginster},
  journal={Acta endocrinologica},
  year={1989},
  volume={120 1},
  pages={121-8}
}
This study sought to determine whether GH response to synthetic GHRH was impaired in 13 postmenopausal (55-71 years) as compared with that in 8 eugonadal women and whether IGF-I and bone metabolism were consequently depressed. Thereafter, the effects of daily iv injections of 80-micrograms GHRH-44 for 8 days were studied in the same postmenopausal group. In addition to significantly higher basal IGF-I and osteocalcin levels (P less than 0.005) in eugonadal as compared with the postmenopausal… CONTINUE READING