Effects of repeated stress on T cell numbers and function in rats

  title={Effects of repeated stress on T cell numbers and function in rats},
  author={Olcay A. Batuman and D H Sajewski and John E. Ottenweller and D. Pitman and Benjamin H. Natelson},
  journal={Brain, Behavior, and Immunity},
Although stress has been reported to affect various functions of the immune system, the mechanism that mediate these effects remain unclear. Thus we examined the effects that 1, 7, and 14 days of stress could have on various aspects of immune and endocrine function in rats. Rats subjected to repeated stress (7 and 14 days) showed significant decreases in the total number of mononuclear cells, particularly suppressor/cytotoxic (CD8) T cells, in the spleen and blood. The mitogenic responses of T… CONTINUE READING


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