Effects of repeated fluoxetine on anxiety-related behaviours, central serotonergic systems, and the corticotropic axis axis in SHR and WKY rats.

@article{Durand1999EffectsOR,
  title={Effects of repeated fluoxetine on anxiety-related behaviours, central serotonergic systems, and the corticotropic axis axis in SHR and WKY rats.},
  author={Marl{\`e}ne Durand and Olivier Berton and Sylvie Aguerre and L. Edno and I Combourieu and Pierre Morm{\`e}de and Francis Chaouloff},
  journal={Neuropharmacology},
  year={1999},
  volume={38 6},
  pages={893-907}
}
In keeping with the anxiolytic property of selective serotonin reuptake inhibitors (SSRIs) in humans, we have examined in the spontaneously hypertensive rat (SHR) and the Wistar-Kyoto (WKY) rat, which display low and high anxiety, respectively, some psychoneuroendocrine effects of a repeated treatment with the SSRI fluoxetine (5 or 10 mg/kg daily, for 3 weeks). Two days after the last injection, plasma levels of fluoxetine were not detectable whereas those of its metabolite, norfluoxetine, were… CONTINUE READING