Effects of repeated boluses of sucrose on proliferation and on AOM-induced aberrant crypt foci in rat colon.

@article{Luceri1996EffectsOR,
  title={Effects of repeated boluses of sucrose on proliferation and on AOM-induced aberrant crypt foci in rat colon.},
  author={Cristina Luceri and Giovanna Caderni and L. Lancioni and Silvia Aiolli and Piero Dolara and Vito Mastrandrea and F Scardazza and Guido Morozzi},
  journal={Nutrition and cancer},
  year={1996},
  volume={25 2},
  pages={187-96}
}
Colonic mucosal proliferation, aberrant crypt foci (ACF) induction, and fecal bile acids, parameters connected to the risk of colon cancer development, were studied in female F344 rats treated with starch or sucrose boluses or with a sucrose diet. Cell proliferation was higher in animals treated with a single sucrose bolus than in those given a starch bolus (15 g/kg body wt), with 4.3 +/- 0.64 and 2.17 +/- 0.57 (SE) mitotic figures (MF) per crypt in the sucrose and starch bolus groups… CONTINUE READING

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