Effects of repeated apomorphine and haloperidol treatments on subsequent behavioral sensitivity to apomorphine.

@article{Mattingly1989EffectsOR,
  title={Effects of repeated apomorphine and haloperidol treatments on subsequent behavioral sensitivity to apomorphine.},
  author={Bruce A. Mattingly and J K Rowlett},
  journal={Pharmacology, biochemistry, and behavior},
  year={1989},
  volume={34 2},
  pages={345-7}
}
In a 2 x 2 factorial design, four groups of rats (n = 10 each) were injected daily with haloperidol (0.5 mg/kg IP) or its injection vehicle and apomorphine (1.0 mg/kg SC) or its vehicle for 21 consecutive days. Then, following a six-day drug-free rest interval, all rats were tested for locomotor activity in photocell arenas after an apomorphine injection on four additional days. Major findings were as follows: (a) rats pretreated with apomorphine were significantly more active following an… CONTINUE READING

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