Effects of renal medullary and intravenous norepinephrine on renal antihypertensive function.

@article{Correia2000EffectsOR,
  title={Effects of renal medullary and intravenous norepinephrine on renal antihypertensive function.},
  author={Anabela G. Correia and Anna C. Madden and G{\"o}ran Bergstr{\"o}m and Roger G Evans},
  journal={Hypertension},
  year={2000},
  volume={35 4},
  pages={965-70}
}
Increasing renal arterial pressure activates at least 3 antihypertensive mechanisms: reduced renin release, pressure natriuresis, and release of a putative renal medullary depressor hormone. To examine the role of renal medullary perfusion in these mechanisms, we tested the effects of the infusion of norepinephrine, either infusion into the renal medullary interstitium or intravenous infusion, on responses to increased renal arterial pressure in pentobarbital-anesthetized rabbits. We used an… CONTINUE READING