Effects of renal impairment on transporter-mediated renal reabsorption of drugs and renal drug-drug interactions: A simulation-based study.

@article{Follman2018EffectsOR,
  title={Effects of renal impairment on transporter-mediated renal reabsorption of drugs and renal drug-drug interactions: A simulation-based study.},
  author={Kristin E. Follman and Rutwij A. Dave and Marilyn E Morris},
  journal={Biopharmaceutics & drug disposition},
  year={2018},
  volume={39 4},
  pages={
          218-231
        }
}
Renal impairment (RI) significantly impacts the clearance of drugs through changes in the glomerular filtration rate, protein binding and alterations in the expression of renal drug transport proteins and hepatic metabolizing enzymes. The objectives of this study were to evaluate quantitatively the effects of renal impairment on the pharmacokinetics of drugs undergoing renal transporter-mediated reabsorption. A previously published semi-mechanistic kidney model incorporating physiologically… CONTINUE READING

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Effects of renal impairment on transporter‐mediated renal reabsorption of drugs and renal drug–drug interactions: A simulation‐based study

KE Follman, RA Dave, ME. Morris
  • Biopharm Drug Dispos. 2018;39:218–231
  • 2018