Effects of renal denervation on sodium balance and renal function during chronic furosemide administration in rats.

@article{Petersen1992EffectsOR,
  title={Effects of renal denervation on sodium balance and renal function during chronic furosemide administration in rats.},
  author={Jorgen Soberg Petersen and Gerald F. Dibona},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1992},
  volume={262 3},
  pages={
          1103-9
        }
}
In order to investigate whether the renal nerves are involved in the compensatory response of increased renal tubular Na reabsorption, which limits the natriuretic response during chronic furosemide treatment (the "braking phenomenon"), daily Na balance measurements were performed in rats with either renal denervation (DNX) or sham denervation (Sham-DNX) infused i.p. for 5 days with furosemide (Fur) (0.5 mg/hr) or vehicle (Veh) (10 microliters/hr) (n = 8 in each group). Renal denervation… CONTINUE READING

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