Effects of reduced electrochemical Na+ gradient on contractility in skeletal muscle: role of the Na+-K+ pump

@article{Overgaard1997EffectsOR,
  title={Effects of reduced electrochemical Na+ gradient on contractility in skeletal muscle: role of the Na+-K+ pump},
  author={K. Overgaard and Ole B{\ae}kgaard Nielsen and Torben Clausen},
  journal={Pfl{\"u}gers Archiv},
  year={1997},
  volume={434},
  pages={457-465}
}
 Continued excitation of skeletal muscle may induce a combination of a low extracellular Na+ concentration ([Na+]o) and a high extracellular K+ concentration ([K+]o) in the T-tubular lumen, which may contribute to fatigue. Here, we examine the role of the Na+-K+ pump in the maintenance of contractility in isolated rat soleus muscles when the Na+, K+ gradients have been altered. When [Na+]o is lowered to 25 mM by substituting Na+ with choline, tetanic force is decreased to 30% of the control… CONTINUE READING