Effects of reduced Gcm1 expression on trophoblast morphology, fetoplacental vascularity, and pregnancy outcomes in mice.

@article{Bainbridge2012EffectsOR,
  title={Effects of reduced Gcm1 expression on trophoblast morphology, fetoplacental vascularity, and pregnancy outcomes in mice.},
  author={Shannon Bainbridge and Abhijeet Minhas and K. Whiteley and Dawei Qu and John G. Sled and John C. P. Kingdom and Susan Lee Adamson},
  journal={Hypertension},
  year={2012},
  volume={59 3},
  pages={732-9}
}
Preeclampsia is a life-threatening disorder characterized by maternal gestational hypertension and proteinuria that results from placental dysfunction. Placental abnormalities include abnormal syncytiotrophoblast and a 50% reduction in placental expression of the transcription factor Gcm1. In mice, homozygous deletion of Gcm1 prevents syncytiotrophoblast differentiation and is embryonic lethal. We used heterozygous Gcm1 mutants (Gcm1(+/-)) to test the hypothesis that hypomorphic expression of… CONTINUE READING

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