Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

@article{Farooqi1999EffectsOR,
  title={Effects of recombinant leptin therapy in a child with congenital leptin deficiency.},
  author={I Sadaf Farooqi and Susan A Jebb and Gill Langmack and Elizabeth C. Lawrence and C. H. Cheetham and Andrew M. Prentice and Ieuan A. Hughes and Mark Anthony Mccamish and Stephen O'Rahilly},
  journal={The New England journal of medicine},
  year={1999},
  volume={341 12},
  pages={
          879-84
        }
}
Severely obese (ob/ob) mice are deficient in the adipocyte-derived hormone leptin, which acts on the hypothalamus to control appetite and energy expenditure.1 The administration of leptin to these mice corrects their obesity by reducing their food intake and increasing their energy expenditure.2–4 These mice also have hyperinsulinemia, corticosterone excess, and infertility, which also are reversed by treatment with leptin.5 In humans, serum leptin concentrations, in general, correlate… CONTINUE READING

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