Effects of recombinant human keratinocyte growth factor on surfactant, plasma, and liver phospholipid homeostasis in hyperoxic neonatal rats.

@article{Raith2012EffectsOR,
  title={Effects of recombinant human keratinocyte growth factor on surfactant, plasma, and liver phospholipid homeostasis in hyperoxic neonatal rats.},
  author={Marco Raith and Katharina Schaal and Roland Koslowski and Heinz Fehrenbach and Christian F. Poets and Erwin D. Schleicher and Wolfgang Bernhard},
  journal={Journal of applied physiology},
  year={2012},
  volume={112 8},
  pages={
          1317-28
        }
}
Respiratory distress and bronchopulmonary dysplasia (BPD) are major problems in preterm infants that are often addressed by glucocorticoid treatment and increased oxygen supply, causing catabolic and injurious side effects. Recombinant human keratinocyte growth factor (rhKGF) is noncatabolic and antiapoptotic and increases surfactant pools in immature lungs. Despite its usefulness in injured neonatal lungs, the mechanisms of improved surfactant homeostasis in vivo and systemic effects on lipid… 

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