Effects of recombinant human basic fibroblast growth factor and its modified protein CS23 on survival of primary cultured neurons from various regions of fetal rat brain.

@article{Abe1990EffectsOR,
  title={Effects of recombinant human basic fibroblast growth factor and its modified protein CS23 on survival of primary cultured neurons from various regions of fetal rat brain.},
  author={Kazuho Abe and Motoaki Takayanagi and Hiroko Saito},
  journal={Japanese journal of pharmacology},
  year={1990},
  volume={53 2},
  pages={221-7}
}
Neutrophic effects of recombinant human basic fibroblast growth factor (hbFGF) and its modified protein CS23 on brain neurons were evaluated by their abilities to promote survival of primary cultured neurons from various regions of fetal rat brain. In the molecule of CS23, two serines are substituted for two cysteines at positions 70 and 88 in the natural hbFGF. Both hbFGF and CS23 markedly increased the survival of cultured neurons from all regions tested, i.e., cerebral cortex, septum… CONTINUE READING

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