Effects of recombinant human IGF-I and oral contraceptive administration on bone density in anorexia nervosa.

@article{Grinspoon2002EffectsOR,
  title={Effects of recombinant human IGF-I and oral contraceptive administration on bone density in anorexia nervosa.},
  author={Steven K Grinspoon and Lisa K. Thomas and Karen Klahr Miller and David B. Herzog and Anne Klibanski},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2002},
  volume={87 6},
  pages={2883-91}
}
Over 90% of women with anorexia nervosa demonstrate osteopenia, and almost 40% demonstrate osteoporosis at one or more skeletal sites. In addition to estrogen deficiency causing an increase in bone resorption, nutritional effects on the GH-IGI-I axis may contribute to the severe bone loss in this population by decreasing bone formation. We tested the hypothesis that recombinant human IGF-I (rhIGF-I) would increase bone density in women with anorexia nervosa and furthermore assessed the effects… CONTINUE READING
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