Effects of receptor tyrosine kinase inhibitor A47 on estrogen and growth factor-dependent breast cancer cell proliferation and apoptosis in vitro.

@article{Turbov2002EffectsOR,
  title={Effects of receptor tyrosine kinase inhibitor A47 on estrogen and growth factor-dependent breast cancer cell proliferation and apoptosis in vitro.},
  author={Jane M Turbov and George M Twaddle and Xiao Yang and Naxin M Liu and S. Krishna Murthy},
  journal={Journal of surgical oncology},
  year={2002},
  volume={79 1},
  pages={17-29}
}
BACKGROUND AND OBJECTIVES We propose that a growth factor receptor tyrosine kinase (RTK) inhibitor, such as tyrphostin A47, could serve as an adjunct to estrogen replacement therapy (ERT) for postmenopausal breast cancer survivors. Tyrphostins have been shown to block estrogen (E2)-induced proliferation in the human breast cancer MCF-7 cell line. Therefore… CONTINUE READING