Effects of receptor binding specificity of avian influenza virus on the human innate immune response.


Humans infected by the highly pathogenic H5N1 avian influenza viruses (HPAIV) present unusually high concentrations in serum of proinflammatory cytokines and chemokines, which are believed to contribute to the high pathogenicity of these viruses. The hemagglutinins (HAs) of avian influenza viruses preferentially bind to sialic acids attached through α2,3… (More)
DOI: 10.1128/JVI.02356-10

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