Effects of reboxetine and sertraline treatments alone and in combination on the binding properties of cortical NMDA and β1-adrenergic receptors in an animal model of depression

  title={Effects of reboxetine and sertraline treatments alone and in combination on the binding properties of cortical NMDA and $\beta$1-adrenergic receptors in an animal model of depression},
  author={Andrew Harkin and Rachel E. Nally and John P Kelly and Brian E. Leonard},
  journal={Journal of Neural Transmission},
Summary. Changes to the binding properties of cortical N-methyl-D-aspartic acid (NMDA) and beta-adrenergic receptors have both been reported as potential indicators of antidepressant activity. In the present investigation we examined the effects of the noradrenaline reuptake inhibitor, reboxetine, the serotonin reuptake inhibitor, sertraline, alone and in combination on the binding properties of cortical NMDA receptors and cortical β1-adrenoceptors following 14 days of treatment in the… Expand
Antidepressant-like effect of tramadol in the unpredictable chronic mild stress procedure: possible involvement of the noradrenergic system
The view that the noradrenergic system plays an important role in the antidepressant-like action of tramadol is supported. Expand
The promises and pitfalls of reboxetine.
  • M. Page
  • Psychology, Medicine
  • CNS drug reviews
  • 2003
Reboxetine has been a valuable pharmacological tool to assess the role of the noradrenergic system in preclinical studies of depressive disorder and its use as an antidepressant is currently limited to Europe. Expand
Reboxetine: functional inhibition of monoamine transporters and nicotinic acetylcholine receptors.
In addition to inhibition of NET function, reboxetine inhibits nAChR function, suggesting that it may have potential as a smoking cessation agent. Expand
Medium supplementation with zinc enables detection of imipramine-induced adaptation in glycine/NMDA receptors labeled with [3H]L-689,560.
The present data indicate that [3H]L-689,560 may be a suitable ligand for assessing adaptation of the glycine/NMDA sites and the presence of zinc enhances detection of imipramine-induced reduction of glycine affinity for glycine/. Expand
Simultaneous analyses of the neurochemical and behavioral effects of the norepinephrine reuptake inhibitor reboxetine in a rat model of antidepressant action
Treatment with reboxetine in a schedule commonly used in the FST resulted in a potentiated noradrenergic response to the swim challenge concomitant with behavioral alterations consistent with antidepressant-like activity. Expand
Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine‐induced down‐regulation of β‐adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands
The time required for the antidepressant imipramine to reduce the expression of β‐adrenergic receptors in the hippocampus is reduced by a co‐administration with centrally active ligands of type 2/3 metabotropic glutamate (mGlu2/3) receptors. Expand
Sertraline behavioral response associates closer and dose-dependently with cortical rather than hippocampal serotonergic activity in the rat forced swim stress
Results indicate that after antidepressant treatment, behavior during the FST can be predictive of respective serotonergic changes, especially in the prefrontal cortex, as well as subchronic sertraline treatment. Expand
Central monoamines and their role in major depression
  • A. S. Elhwuegi
  • Medicine, Psychology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2004
Blocking the somatodendritic 5-HT(1A) or nerve terminal alpha(2) receptors proved to increase the response rate in the treatment of major and treatment-resistant depression, providing further support to the assumption that the antidepressant effect results from the long-term adaptive changes in the monoamine auto- and heteroregulatory receptors. Expand
Linalool and β-pinene exert their antidepressant-like activity through the monoaminergic pathway.
The results indicate that linalool and β-pinene produce an antidepressant-like effect through interaction with the monoaminergic system. Expand
The selective norepinephrine reuptake inhibitor antidepressant reboxetine: pharmacological and clinical profile.
In vitro and in vivo pharmacological studies indicated that reboxetine methanesulphonate has high affinity and selectivity for the human norepinephrine transporter over the serotonin and dopamine transporters, which has provided the psychopharmacology community with a tool to elucidate the role of nore Alpinephrine in brain functions. Expand


Activity and onset of action of reboxetine and effect of combination with sertraline in an animal model of depression.
Results indicate that changes to 8-OH-DPAT and clonidine-induced responses occur quicker with the combination treatment than with either reboxetine or sertraline treatments alone, and also indicates changes to 5-HT1A receptor and alpha2-adrenoceptor sensitivity. Expand
Calcium antagonists in the olfactory bulbectomy animal model of depression: effect on the cortical NMDA receptor complex.
  • G. Nowak
  • Chemistry, Medicine
  • Polish journal of pharmacology
  • 1996
Verapamil and diltiazem are not effective in OB model of depression, VDCC antagonists'-induced effect in the glycine sites of the NMDA receptor complex is not species-specific, and there is no direct relationship between OB-induced hyperactivity and alterations in strychnine-insensitive glycine Sites of theNMDA receptorcomplex. Expand
Adaptation of the NMDA receptor in rat cortex following chronic electroconvulsive shock or imipramine.
The ability of chronic antidepressant treatments to induce adaptive changes in the glycine and glutamate regulatory sites of the NMDA receptor is not species specific, since it obtains in rats as well as mice. Expand
NMDA Receptors and Affective Disorders
In both behavioral and biochemical screening procedures, antagonists at the NMDA receptor complex behave in a manner comparable to clinically active antidepressants. Expand
Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments.
The ability of antidepressants drawn from every principal therapeutic class to effect adaptive changes in the N-methyl-D-aspartate receptor complex is consistent with the hypothesis that this ligand-gated ion channel serves as a final common pathway of antidepressant action and indicates that glutamatergic pathways may be involved in the pathophysiology of depression. Expand
Adaptive changes in the N-methyl-D-aspartate receptor complex after chronic treatment with imipramine and 1-aminocyclopropanecarboxylic acid.
Findings indicate that adaptive changes in the NMDA receptor complex could be a feature common to chronic treatment with structurally unrelated antidepressants. Expand
Desipramine administration in the olfactory bulbectomized rat: changes in brain β‐adrenoceptor and 5‐HT2A binding sites and their relationship to behaviour
The present results suggest that the action of DMI in this animal model is unlikely to be directly related to a reduction in β‐adrenoceptors but may be related toA reduction in frontal cortical 5‐HT2A receptors. Expand
Antidepressant treatments, including sibutramine hydrochloride and electroconvulsive shock, decrease beta 1- but not beta 2-adrenoceptors in rat cortex.
The beta 1- and beta 2-adrenoceptor populations in rat cortex were individually quantified by labelling all of the receptors with [3H]dihydroalprenolol and displacing with isoprenaline or CGP 20712A and the results of 3 days of administration or a single ECS were determined. Expand
Adaptation of cortical but not hippocampal NMDA receptors after chronic citalopram treatment.
The results support the hypotheses that: (1) the adaptation of strychnine-insensitive glycine recognition sites and the allosteric coupling of the glycine and glutamate recognition sites are independently regulated by chronic antidepressant treatment; and (2) chronic antidepressant administration induces regionally selective adaptation of the NMDA receptor complex. Expand
Combining pindolol and paroxetine in an animal model of chronic antidepressant action--can early onset of action be detected?
The ability of the combination group to attenuate the hypothermic effects of 8-OH-DPAT much faster further emphasises the role of the 5-HT1A receptor in the mechanism of action of antidepressants and as a target for the development of faster acting antidepressants. Expand