Effects of reboxetine and sertraline treatments alone and in combination on the binding properties of cortical NMDA and β1-adrenergic receptors in an animal model of depression

@article{Harkin2000EffectsOR,
  title={Effects of reboxetine and sertraline treatments alone and in combination on the binding properties of cortical NMDA and $\beta$1-adrenergic receptors in an animal model of depression},
  author={Andrew Harkin and Rachel E. Nally and John P Kelly and Brian E. Leonard},
  journal={Journal of Neural Transmission},
  year={2000},
  volume={107},
  pages={1213-1227}
}
Summary. Changes to the binding properties of cortical N-methyl-D-aspartic acid (NMDA) and beta-adrenergic receptors have both been reported as potential indicators of antidepressant activity. In the present investigation we examined the effects of the noradrenaline reuptake inhibitor, reboxetine, the serotonin reuptake inhibitor, sertraline, alone and in combination on the binding properties of cortical NMDA receptors and cortical β1-adrenoceptors following 14 days of treatment in the… Expand
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