Effects of rearing temperature on sympathoadrenal activity in young adult rats.

@article{Young2002EffectsOR,
  title={Effects of rearing temperature on sympathoadrenal activity in young adult rats.},
  author={James B. De Young and Jeffrey R Weiss and Nadine Boufath},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2002},
  volume={283 5},
  pages={R1198-209}
}
Animals reared at 18 degrees C exhibit enhanced innervation of brown adipose tissue (BAT) and greater cold tolerance as adults, yet gain more weight when fed an enriched diet compared with rats reared at 30 degrees C. To explore this paradox, sympathoadrenal activity was examined using techniques of [(3)H]norepinephrine ([(3)H]NE) turnover and urinary catecholamine excretion in male and female rats reared until 2 mo of age at 18 or 30 degrees C. Gene expression in BAT was also analyzed for… CONTINUE READING

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Although [ ( 3)H]NE turnover in heart did not differ between groups , [ ( 3)H]NE turnover in BAT was consistently elevated in the 18 degrees C - reared animals , even 2 mo after removal from the cool environment . Gene expression for uncoupling proteins 1 and 3 , GLUT-4 , leptin , and the alpha(1A)-adrenergic receptor was more abundant in BAT and the increase in epinephrine excretion with fasting suppressed in 18 degrees C - reared animals .
Although [ ( 3)H]NE turnover in heart did not differ between groups , [ ( 3)H]NE turnover in BAT was consistently elevated in the 18 degrees C - reared animals , even 2 mo after removal from the cool environment . Gene expression for uncoupling proteins 1 and 3 , GLUT-4 , leptin , and the alpha(1A)-adrenergic receptor was more abundant in BAT and the increase in epinephrine excretion with fasting suppressed in 18 degrees C - reared animals .
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