Effects of reactive oxygen species on brain synaptic plasma membrane Ca(2+)-ATPase.

  title={Effects of reactive oxygen species on brain synaptic plasma membrane Ca(2+)-ATPase.},
  author={A. G. Zaidi and Mary L. Michaelis},
  journal={Free radical biology & medicine},
  volume={27 7-8},
The regulation of free intracellular calcium [Ca2+]i is altered in neurons from the aged brain, possibly due to reductions in the activity of Ca2+ transporters. The plasma membrane Ca(2+)-ATPase (PMCA) plays a critical role in Ca2+ homeostasis, and its kinetic properties change in aged rat brain. These changes could be due to oxidative modification of PMCA as a result of age-related chronic oxidative stresses. The present studies were undertaken to determine the sensitivity of the neuronal PMCA… CONTINUE READING


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