Effects of rapamycin and TOR on aging and memory: implications for Alzheimer's disease.

@article{Santos2011EffectsOR,
  title={Effects of rapamycin and TOR on aging and memory: implications for Alzheimer's disease.},
  author={Renato X. Santos and S{\'o}nia Catarina Correia and Susana M Cardoso and Cristina Isabel Carvalho and Maria Santos and Paula I Moreira},
  journal={Journal of neurochemistry},
  year={2011},
  volume={117 6},
  pages={927-36}
}
Rapamycin is a macrolide immunosuppressant drug, originally used as an anti-fungal agent, which is widely used in transplantation medicine to prevent organ rejection. Target of rapamycin (TOR) is an evolutionarily conserved serine/threonine kinase with pleiotropic cellular functions, regulating processes such as growth and metabolism, cell survival, transcription and autophagy. TOR intervenes in two distinct enzymatic complexes with different functions, a rapamycin-sensitive complex TORC1 and a… CONTINUE READING

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