Effects of ramelteon (TAK-375) on nocturnal sleep in freely moving monkeys.

@article{Yukuhiro2004EffectsOR,
  title={Effects of ramelteon (TAK-375) on nocturnal sleep in freely moving monkeys.},
  author={Nobuhito Yukuhiro and Hiroyuki Kimura and Hisao Nishikawa and Shigenori Ohkawa and Shin-ichi Yoshikubo and Masaomi Miyamoto},
  journal={Brain research},
  year={2004},
  volume={1027 1-2},
  pages={59-66}
}
We investigated the effects of (S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno-[5,4]furan-8-yl)ethyl]propionamide (ramelteon, TAK-375), a novel MT1/MT2 receptor agonist, on nocturnal sleep in freely moving monkeys and compared these results with those of melatonin and zolpidem. Treatment with ramelteon (0.03 and 0.3 mg/kg, p.o.) significantly shortened latency to sleep onset and significantly increased total duration of sleep. Treatment with melatonin (0.3, 1, and 3 mg/kg, p.o.) also decreased sleep… CONTINUE READING

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