Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials

@article{Clarke2006EffectsOR,
  title={Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials},
  author={Mike Clarke and Rory Collins and Sarah C. Darby and Christina Davies and Penelope Elphinstone and Vaughan Evans and Jon Godwin and Richard Gray and Chindo Hicks and Sam James and E Mackinnon and P. A. Mcgale and Theresa McHugh and Richard Peto and C W Taylor and Y C Wang},
  journal={The Lancet},
  year={2006},
  volume={366},
  pages={2087-2106}
}

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References

SHOWING 1-10 OF 49 REFERENCES

Effects of radiotherapy and surgery in early breast cancer. An overview of the randomized trials.

Some of the local therapies for breast cancer had substantially different effects on the rates of local recurrence--such as the reduced recurrence with the addition of radiotherapy to surgery--but there were no definite differences in overall survival at 10 years.

Late local recurrences in a randomised trial comparing conservative treatment with total mastectomy in early breast cancer patients.

Late breast recurrences were more frequently observed in younger patients treated with breast-conserving treatment compared with those submitted to mastectomy, and this treatment effect was greater among younger patients.

Breast-conserving surgery with or without radiotherapy: pooled-analysis for risks of ipsilateral breast tumor recurrence and mortality.

Omission of radiotherapy is associated with a large increase in risk of ipsilateral breast tumor recurrence and with a small increase in the risk of patient mortality.

Re: Breast-conserving surgery with or without radiotherapy: pooled-analysis for risks of ipsilateral breast tumor recurrence and mortality.

Omission of radiotherapy is associated with a large increase in risk of ipsilateral breast tumor recurrence and with a small increase in the risk of patient mortality.

Differences in risk factors for local and distant recurrence after breast-conserving therapy or mastectomy for stage I and II breast cancer: pooled results of two large European randomized trials.

Age no more than 35 years and the presence of an extensive intraductal component are associated with an increased risk of local recurrence after breast-conserving therapy and should therefore not be used for deciding between the two treatments.

Locoregional radiation therapy in patients with high-risk breast cancer receiving adjuvant chemotherapy: 20-year results of the British Columbia randomized trial.

For patients with high-risk breast cancer treated with modified radical mastectomy, treatment with radiation therapy and adjuvant chemotherapy leads to better survival outcomes than chemotherapy alone, and it is well tolerated, with acceptable long-term toxicity.

Does locoregional radiation therapy improve survival in breast cancer? A meta-analysis.

Locoregional radiation after surgery in patients treated with systemic therapy reduced mortality and several questions remain on how these results should be translated into current-day clinical practice.

Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer.

Lumpectomy followed by breast irradiation continues to be appropriate therapy for women with breast cancer, provided that the margins of resected specimens are free of tumor and an acceptable cosmetic result can be obtained.