Effects of radiation on T regulatory cells in normal states and cancer: mechanisms and clinical implications.

@article{Liu2015EffectsOR,
  title={Effects of radiation on T regulatory cells in normal states and cancer: mechanisms and clinical implications.},
  author={Shu Liu and Xiangdong Sun and Jinhua Luo and Hongcheng Zhu and X Yang and Qing Guo and Yaqi Song and Xinchen Sun},
  journal={American journal of cancer research},
  year={2015},
  volume={5 11},
  pages={3276-85}
}
Radiation remains an important component of cancer treatment. In addition to inducing tumor cell death through direct cytotoxic effects, radiation can also promote the regression of tumor via augment of immune response. Regulatory T cells (Tregs) are a unique subpopulation of CD4 positive cells, which are characterized by expression of the forkhead box P3 (Foxp3) transcription factor and high levels of CD25. Mounting evidence has shown that Tregs are implicated in the development and… CONTINUE READING