• Corpus ID: 25614116

Effects of quinidine on the cardiac-glycoside sensitivity of guinea-pig and rat heart.

  title={Effects of quinidine on the cardiac-glycoside sensitivity of guinea-pig and rat heart.},
  author={D H Kim and Tai Akera and Theodore M. Brody},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={217 3},
  • D. KimT. AkeraT. Brody
  • Published 1 June 1981
  • Biology, Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
Quinidine causes a marked increase in plasma digoxin concentration in patients receiving the glycoside. Whether the sensitivity of the heart to digoxin is altered by quinidine was examined with rats and guinea pigs. In electrically stimulated rat atrial preparations, quinidine failed to affect digoxin-induced inhibition of ouabain-sensitive 42K+ uptake, an estimate of sodium pump activity. Effects of quinidine on digoxin binding to Na+, K+-adenosine triphosphatase (ATPase) in intact cells were… 

Effect of quinidine on the inotropic effect of digoxin in isolated cat or guinea-pig papillary muscle

Data suggest that an interaction between quinidine and digoxin exists in isolated cat papillary muscle, but this interaction is not apparent in guinea-pig muscle, therefore, when studying the interaction between these two drugs, the choice of the animal species used may be important.

Effect of quinidine on the tissue binding of digoxin in guinea‐pigs

It is concluded that quinidine‐induced decrease in the tissue distribution of digoxin in heart and muscle is due to inhibition of tissue binding of this drug, while that in liver could be partially attributed to the decrease inthe tissue binding.

Effect of quinidine on digoxin distribution and elimination in guinea pigs.

It was concluded that quinidine caused a inhibition ofdigoxin in the tissue binding or uptake, which significantly decreased the Kp values of digoxin; this result may explain the significant decrease of Vdss.

Myocardial Monovalent Cation Transport during the Quinidine‐Digoxin Interaction in Dogs

During the quinidine-digoxin interaction in the intact dog, the reduction in myocardial rubidium uptake is less than expected from the increase in serum digoxin concentration.

Influence of quinidine on the binding of [3H]-ouabain and [3H]-digoxin by human lymphocytes

A therapeutic concentration of quinidine does not affect the number of glycoside receptors on lymphocytes, but it does appear to reduce fractional receptor occupancy by both [ 3H]-ouabain and [3H]-digoxin at lower tracer concentrations.

Transport of digoxin into brain microvessels and choroid plexuses isolated from guinea pig.

It is suggested that digoxin can be excreted from both the brain and the cerebrospinal fluid to blood by a carrier-mediated diffusion system which is inhibited by quinidine, and that a main route of digoxin efflux from the brain to the blood is not through the blood-CSF barrier, but through theBlood-brain barrier.

Quinidine decreases the intestinal secretion of digoxin and digitoxin in the guinea-pig

The secretion of digoxin and digitoxin into in situ perfused jejunal and colonic segments of normal or quinidine treated guinea-pigs was studied. Quinidine was administered intravenously by constant