Effects of quazepam as a preoperative night hypnotic: comparison with brotizolam

  title={Effects of quazepam as a preoperative night hypnotic: comparison with brotizolam},
  author={Tomoki Nishiyama and Koichi Yamashita and Takeshi Yokoyama and Akinobu Imoto and Masanobu Manabe},
  journal={Journal of Anesthesia},
PurposeThe purpose of this study was to evaluate the effects of quazepam, a long-acting hypnotic, as a preoperative night medication in comparison with brotizolam, a shortacting hypnotic.MethodsTwo hundred patients (aged 30 to 70 years) admitted for elective general anesthesia at various hospitals were enrolled. Quazepam 15 mg, 30 mg, or 45 mg, or brotizolam 0.25 mg (40 patients each), was administered orally at 9 p.m. in the evening of the day before surgery. The control group (40 patients… 
Dreams, Sleep, and Psychotropic Drugs
The reduction of intra-sleep awakenings seems to be the parameter explaining best the modulation of DRF by psychotropic drugs, which is coherent with the “arousal-retrieval model” stating that nighttime awakenings enable dreams to be encoded into long-term memory and therefore facilitate dream recall.
A pragmatic evaluation of sleep patterns before gynecologic surgery
Using logistic regression, it was found that age, stress level, and time before surgery, were significant predictors of poor sleep and the type of planned surgery did not influence the quality of sleep.


Quazepam versus triazolam in patients with sleep disorders: a double-blind study.
In conclusion, quazepam seems to have a good hypnotic effect without inducing rebound effects, while triazolam turned out to be just a hypnoinducent drug with higher risks of rebound effects after withdrawal.
Brotizolam as a pre-operative hypnotic.
Brontizolam maintained sleep throughout the night more effectively than flunitrazepam and was found to be effective and well tolerated as a preoperative hypnotic.
A Clinical Study of Quazepam in Hospitalized Patients with Insomnia
Quazepam demonstrated greater improvement in Hypnotic Activity Index and Sleep Quality Index from baseline scores, and caused no adverse reactions.
The sedative-hypnotic properties of quazepam, a new hypnotic agent.
In conscious, unrestrained squirrel monkeys and cats, quazepam produced sedation with less ataxia and less evidence of CNS stimulant action than flurazepAM, which should be an effective hypnotic with less potential for ataxIA, paradoxical excitation, and tolerance than florinol.
Feasibility of an every-other-night regimen in insomniac patients: subjective hypnotic effectiveness of quazepam, triazolam, and placebo.
  • M. Scharf
  • Medicine
    The Journal of clinical psychiatry
  • 1993
The efficiency of alternate-night therapy with quazepam should be rigorously evaluated using polysomnographic determinations.
[Electroencephalographic study of Sch 161 (quazepam), a new benzodiazepine hypnotic, in rats and rabbits].
The results suggest that the EEG effect of quzepam is different to those of flurazepam and diazepam in qualitative aspects and that quazEPam is likely to be an effective sleep-promoting drug with slight adverse reactions.
Efficacy of lorazepam oral fast dissolving drug formulation (FDDF) in anesthesia premedication in adults: a double-blind placebo controlled comparison.
Lorazepam FDDF (fast dissolving drug formulation) appeared to be an effective and clinically safe premedicant for its good anxiolytic and amnestic effect and its high acceptance by the patients.
The Effect of a New Benzodiazepine on the Polygraphically Monitored Sleep of Normal Volunteers
The subjective quality of sleep was improved by the new benzodiazepine hypnotic, and one subject reported that he felt lethargic the day after the largest dose.
Pharmacokinetics and metabolism of brotizolam in humans.
  • W. Bechtel
  • Medicine, Biology
    British journal of clinical pharmacology
  • 1983
In healthy young volunteers as well as in elderly patients, there was neither a tendency for brotizolam to accumulate nor was there any indication of enzyme induction, and the drug was metabolized almost completely into hydroxylated compounds which were conjugated before renal excretion.