Effects of quazepam as a preoperative night hypnotic: comparison with brotizolam

  title={Effects of quazepam as a preoperative night hypnotic: comparison with brotizolam},
  author={Tomoki Nishiyama and Koichi Yamashita and Takeshi Yokoyama and Akinobu Imoto and Masanobu Manabe},
  journal={Journal of Anesthesia},
PurposeThe purpose of this study was to evaluate the effects of quazepam, a long-acting hypnotic, as a preoperative night medication in comparison with brotizolam, a shortacting hypnotic.MethodsTwo hundred patients (aged 30 to 70 years) admitted for elective general anesthesia at various hospitals were enrolled. Quazepam 15 mg, 30 mg, or 45 mg, or brotizolam 0.25 mg (40 patients each), was administered orally at 9 p.m. in the evening of the day before surgery. The control group (40 patients… 

Dreams, Sleep, and Psychotropic Drugs

The reduction of intra-sleep awakenings seems to be the parameter explaining best the modulation of DRF by psychotropic drugs, which is coherent with the “arousal-retrieval model” stating that nighttime awakenings enable dreams to be encoded into long-term memory and therefore facilitate dream recall.

A pragmatic evaluation of sleep patterns before gynecologic surgery

Using logistic regression, it was found that age, stress level, and time before surgery, were significant predictors of poor sleep and the type of planned surgery did not influence the quality of sleep.



Quazepam versus triazolam in patients with sleep disorders: a double-blind study.

In conclusion, quazepam seems to have a good hypnotic effect without inducing rebound effects, while triazolam turned out to be just a hypnoinducent drug with higher risks of rebound effects after withdrawal.

Quazepam in the short-term treatment of insomnia in outpatients.

Overall, quazepam 30 mg was a safe and effective hypnotic, with significant hypnotic activity on the first night of administration.

A Clinical Study of Quazepam in Hospitalized Patients with Insomnia

Quazepam demonstrated greater improvement in Hypnotic Activity Index and Sleep Quality Index from baseline scores, and caused no adverse reactions.

The sedative-hypnotic properties of quazepam, a new hypnotic agent.

In conscious, unrestrained squirrel monkeys and cats, quazepam produced sedation with less ataxia and less evidence of CNS stimulant action than flurazepAM, which should be an effective hypnotic with less potential for ataxIA, paradoxical excitation, and tolerance than florinol.

Feasibility of an every-other-night regimen in insomniac patients: subjective hypnotic effectiveness of quazepam, triazolam, and placebo.

  • M. Scharf
  • Medicine
    The Journal of clinical psychiatry
  • 1993
The efficiency of alternate-night therapy with quazepam should be rigorously evaluated using polysomnographic determinations.

Quazepam, A New Benzodiazepine Hypnotic: Intermediate‐Term Sleep Laboratory Evaluation

Data regarding long-term safety or tolerance of the drug suggest that quazepam is well tolerated and that its pharmacological effects are similar to those of other benzodiazepines.

Quazepam kinetics in the elderly

Comparison of these data with reported kinetic data in young subjects shows that t½βs of quazepam and 2‐oxoquzepam increased only slightly or not at all with age, but that the t½ β of N‐desalkyl‐2‐oxquazep am in the elderly was more than twice that in youngSubjects.

The effects of age and gender on the optimal premedication dose of intramuscular midazolam.

It is indicated that age, but not gender, should affect the i.m. midazolam dose selected for premedication, which would maximize the desired effects and minimize the side effects in a common clinical setting.

Effect of sleep on quazepam kinetics

In general, time of dosing had no appreciable effect on quazepam kinetics or those of its major active plasma metabolites, and the small differences between the two dose times are expected to have clinical significance.