Effects of qinghaosu and related compounds on incorporation of [G-3H] hypoxanthine by Plasmodium falciparum in vitro.

@article{Li1983EffectsOQ,
  title={Effects of qinghaosu and related compounds on incorporation of [G-3H] hypoxanthine by Plasmodium falciparum in vitro.},
  author={Z. Li and H. Gu and D. Warhurst and W. Peters},
  journal={Transactions of the Royal Society of Tropical Medicine and Hygiene},
  year={1983},
  volume={77 4},
  pages={
          522-3
        }
}
  • Z. Li, H. Gu, +1 author W. Peters
  • Published 1983
  • Chemistry, Medicine
  • Transactions of the Royal Society of Tropical Medicine and Hygiene
The effects of qinghaosu (QHS), dihydroqinghaosu (DHQ), artemether and alpha-propoxycarbonyl dihydroartemisine (SM242) on incorporation of [G-3H] hypoxanthine into Plasmodium falciparum were studied in vitro. Antimalarial activity in vitro is enhanced by reduction of the keto group, since DHQ, artemether and SM242 were more than 100 times more active than QHS. 
Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones.
The antimalarial action on Plasmodium falciparum of qinghaosu and artesunate in combination with agents which modulate oxidant stress.
Uptake of [3H] dihydroartemisinine by erythrocytes infected with Plasmodium falciparum in vitro.
In vitro activity of artemisinin, its derivatives, and pyronaridine against different strains of Plasmodium falciparum.
The chemotherapy of rodent malaria, XL. The action of artemisinin and related sesquiterpenes.
Inhibition of growth of Toxoplasma gondii by qinghaosu and derivatives.
Metabolism of antimalarial sesquiterpene lactones.
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