Effects of qinghaosu (artemisinin) and its derivatives on experimental cutaneous leishmaniasis.

@article{Yang1993EffectsOQ,
  title={Effects of qinghaosu (artemisinin) and its derivatives on experimental cutaneous leishmaniasis.},
  author={Duanling Yang and F. K. Y. Liew},
  journal={Parasitology},
  year={1993},
  volume={106 ( Pt 1)},
  pages={
          7-11
        }
}
We have investigated the effect of qinghaosu (QHS, artemisinin) and its derivatives on Leishmania major replication in vitro and on the disease development in mice infected with L. major. Artemisinin is effective against promastigotes in vitro, with an ED50 (50% effective dose) at 7.5 x 10(-7) M. Both artemisinin and artemether are leishmanicidal for amastigotes in infected murine macrophages in vitro, with ED50 at 3 x 10(-5) M and 3 x 10(-6) M respectively. These compounds have no effect on… CONTINUE READING
BETA

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 38 CITATIONS

Similar Papers

Loading similar papers…